Preparation, characterization and antimalarial activity of dihydroartemisinin / ?-cyclodextrin spray-dried powder
نویسندگان
چکیده
In this study a factorial design was used to optimize process conditions produce spray-dried powder of dihydroartemisinin (DHA) with ?-cyclodextrin (?-CD). Predicted for maximum yield and minimum residual moisture were as follows: inlet temperature; 120 °C, aspirator setting; 100%, feed rate; 25%, molar ratio DHA:?-CD; 1:2. The higher percent inclusion obtained in the lower DHA:?-CD. DHA existed amorphous state 1:2 M DHA:?-CD whereas it crystalline 2:1 complex formation between ?-CD revealed by FTIR study. showed dramatically enhanced dissolution rate unchanged antimalarial activity. Moreover, chemically physically stable at 30 75%RH 3 months after storage.
منابع مشابه
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ژورنال
عنوان ژورنال: Journal of Drug Delivery Science and Technology
سال: 2022
ISSN: ['1773-2247', '2588-8943']
DOI: https://doi.org/10.1016/j.jddst.2022.103434